Established in 2022, the Innovation Photonics and Imaging Center (IPIC) is affiliated with the School of Instrument Science and Engineering at Harbin Institute of Technology. It specializes in live-cell super-resolution optical microscopy imaging technology and aims to develop high-end domestic microinstrument products. The research team has been dedicated to establishing a comprehensive framework for biological imaging technology centers and an integrated platform for high-end imaging equipment, providing core imaging tools for precision medicine. This initiative promotes the multimodal integration of life sciences and medicine, positioning cutting-edge technologies as the foundation for future healthcare.
Research Focus:
1) To enhance the spatial resolution of optical microscopes, we propose a mathematical approach to overcome the optical diffraction limit, thereby improving spatial resolution.
2) For high-throughput super-resolution imaging, we introduce a two-step deconvolution method based on autocorrelation, which utilizes pre-deconvolution to boost fluorescence fluctuation detection sensitivity by over two orders of magnitude.
3) To develop a refined reference-free local quality assessment for super-resolution images, we propose rolling Fourier loop correlation technology, enabling in-situ, reference-free quantitative evaluation of super-resolution reconstruction uncertainty at the super-resolution scale.
Profile: Li Haoyu, Professor (Tenured) and Doctoral Supervisor at the School of Instrument Science and Engineering, Harbin Institute of Technology, National Excellent Young Scientist. Research interests include optical super-resolution microscopy, computational imaging techniques, optoelectronic instruments, and holographic optics. In recent years, he has published over 50 papers as first/corresponding author in academic journals such as Nature Biotechnology (impact factor 68.164), Nature Photonics (cover), Nature Communications (2 articles), and Light: Science & Applications. He has delivered over 60 invited presentations at domestic and international academic conferences and filed 20 Chinese patents and 10 international patents. He has led projects funded by the National Natural Science Foundation of China (Youth, Excellent Young, Instrument Special Program) and the National Key R&D Program. He serves as a Youth Committee Member of the China Instrument Society, a Committee Member of the Microscopy Branch of the China Instrument Society, a Committee Member of the Computational Imaging Professional Committee of the China Optical Engineering Society, and a Youth Editorial Board Member of the journal Advances in Laser and Optoelectronics. His achievements were selected twice as one of the Top 10 Social Impact Events in the field of China optics in 2021 and 2023, and were nominated for the Top 10 Advances in China optics (Applied Research Category) in 2022.
Personal homepage: http://homepage.hit.edu.cn/lihaoyu
